Journal
VACCINE
Volume 26, Issue 23, Pages 2899-2905Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.03.042
Keywords
vaccine; Taenia solium cysticercosis; control
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In search of reducing vaccine production costs', a recombinant M13 phage version of the anti-cysticercosis tripeptide vaccine (S3Pvac) was developed. The efficacy of S3Pvac-Phage vs. placebo was evaluated in a randomized trial that included 1047 rural pigs in 16 villages of Central Mexico. Three to five months after vaccination 530 pigs were examined by tongue inspection. At 5-27 months of age, 331 pigs (197 vaccinated/134 controls) were inspected at necropsy. Vaccination reduced 70% the frequency of tongue cysticercosis and, based on necropsy, 54% of muscle-cysticercosis and by 87% the number of cysticerci. (c) 2008 Elsevier Ltd. All rights reserved.
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