Journal
VACCINE
Volume 26, Issue 7, Pages 869-873Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.11.085
Keywords
anthrax; vaccine; IgG; Bacillus anthracis; military
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Funding
- Intramural NIH HHS [Z01 HD008779-03] Funding Source: Medline
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The seroconversion rates and geometric mean concentrations (GMC) of IgG anti-PA for stored sera from U.S. military personnel. immunized 3, 4, and 6 times with the U.S. licensed anthrax vaccine adsorbed were studied. Anti-PA IgG concentrations were measured by ELISA. All. 246 vaccines had low but detectable pre-immunization anti-PA IgG (GMC 1.83 mu g/ml). Three doses elicited a GMC of 59.92 mu g/mL and a seroconversion rate of 85.3%, four doses elicited a GMC of 157.44 mu g/mL and 67.9% and the sixth of 276.95 mu g/ml and 45.5%, respectively. The forth dose elicited 100% seroconversion compared to the pre-immunization level. These results should facilitate comparison between different immunization schedules and new vaccines. Published by Elsevier Ltd.
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