Journal
VACCINE
Volume 26, Issue 24, Pages 3016-3025Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.11.063
Keywords
B cells; HIV-1 vaccination; chemokine receptors
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Induction of broad HIV-1 neutralizing antibodies should be a major goal of an effective HIV-1 vaccine. However, B cells are severely damaged during HIV-1 infection with loss of memory B cells and decline of serological. memory. The molecular events leading to B cell damage must be further characterized with the aim of selecting vaccine components allowing preservation of B cell functions. This review focuses on B cell damage and antibody responses in HIV-1-infected patients during vaccination studies with viral and bacterial. antigens. In addition novel data indicate that B cell activation may be at the basis of impaired immune responses. (c) 2007 Elsevier Ltd. All rights reserved.
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