Journal
VACCINE
Volume 26, Issue -, Pages I40-I45Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.11.060
Keywords
Factor H; Complement; Neisseria meningitidis; Neisseria gonorrhoeae; Serum-resistance; Factor H binding protein
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Funding
- National Institutes of Health [AI054544, AI32725, R01 AI46464]
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Both Neisseria gonorrhoeae and N. meningitidis bind to factor H which enhances their ability to evade complement-dependent killing. While porin is the ligand for human fH on gonococci, meningococci use a lipoprotein called factor H binding protein (fHbp) to bind to factor H and enhance their ability to evade complement-dependent killing. This protein is currently being intensively investigated as a meningococcal vaccine candidate antigen. Consistent with the observation that meningococci cause natural infection only in humans, the organism resists human complement, and are more readily killed by complement from lower animals. This human species-specific complement evasion has important implications for evaluation of vaccine-elicited antibodies using non-human complement sources and development of animal models of disease. (C) 2008 Elsevier Ltd. All rights reserved.
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