Journal
VACCINE
Volume 26, Issue 38, Pages 4947-4954Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.07.016
Keywords
pneumonia; heptavalent pneumococcal conjugate; vaccine; immunity herd
Categories
Funding
- Center for Disease Control and Prevention (CDC)
- Association of Teachers of Preventive Medicine (ATPM)
- [U50 CCU300860 TS-1244]
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Pneumococcal conjugate vaccine use among young children has led to significant declines in invasive pneumococcal disease in the United States, but the impact on community-acquired pneumonia is unknown. We conducted population-based pneumonia Surveillance among 794,282 Group Health members before and after infant vaccine introduction in 2000. We presumptively identified pneumonia episodes using diagnosis codes assigned to medical encounters and confirmed 17,513 Outpatient and 6318 hospitalized events by reviewing chest radiograph reports or hospitalization records. There was evidence for a decline in rates of both outpatient and hospitalized pneumonia in children less than I year of age following vaccine introduction but there were no consistent reductions in pneumonia rates among older children and adults. (C) 2008 Elsevier Ltd. All rights reserved.
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