Journal
VACCINE
Volume 26, Issue 37, Pages 4775-4782Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.07.012
Keywords
respiratory syncytial viruses; DNA vaccines; epitopes; T-lymphocyte
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Funding
- NIAID [R01 AI-53222]
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Cytotoxic T lymphocytes (CTLs) are critical for the control of respiratory syncytial virus infection (RSV) in humans and mice. Recently, we identified anew H-2K(d)-restricted subdominant epitope in the respiratory syncytial virus M2 protein. In this study, we investigated if modification of anchor residues at positions 2 and 9 in the dominant M2(82-90) epitope in the M2 protein would alter the CTL epitope dominance hierarchy following immunization with plasmid DNA encoding M2 proteins. We showed that immunogenicity of the subdominant epitope M2(127-135) was enhanced when the anchor residues of the dominant epitope were mutated, suggesting that the immunodominant epitope induces a Suppression of response to the subdominant epitope. (C) 2008 Elsevier Ltd. All rights reserved.
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