Journal
VACCINE
Volume 26, Issue 26, Pages 3312-3321Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.03.100
Keywords
HIV Tat vaccines; Mauritian cynomolgus macaques; Indian rhesus macaques; MHC haplotypes; host susceptibility/resistance factors
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Funding
- Intramural NIH HHS [Z01 BC005536-21] Funding Source: Medline
- NCRR NIH HHS [P51 RR000167] Funding Source: Medline
- NIAID NIH HHS [N01AI15431, 1 R21 AI 068488-01A2, N01 AI 40088, N01AI40088, R21 AI068488, N01 AI 15431] Funding Source: Medline
- NIH HHS [P51 OD011106] Funding Source: Medline
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Protection afforded by HIV Tat-based vaccines has differed in Indian rhesus and Mauritian cynomolgus macaques. We evaluated native Tat and Ad-HIVtat priming/Tat-boosting regimens in both species. Both vaccines were immunogenic. Only the Ad-tat regimen modestly reduced acute viremia in rhesus macaques after SHIV89.6P challenge. Confounding variables uncovered in Mauritian macaques included significant associations of susceptibility to infection with MHC class IB and class II H2 and H5 haplotypes, and resistance to infection with class IB haplotypes H3 and H6. Although protection here was limited, Tat-based vaccines incorporating other HIV components have shown greater efficacy. Combination strategies should be further explored. Published by Elsevier Ltd.
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