Journal
VACCINE
Volume 26, Issue 41, Pages 5315-5320Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.07.036
Keywords
Cancer vaccines; Listeria; HPV-16
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Funding
- National Institutes of Health [CA69632, KO8 CA097218]
- Elsa U. Pardee Foundation
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We have shown that Listeria-based cancer vaccines inhibit the growth of transplanted tumors in a transgenic mouse model of immune tolerance where HPV-16 E7 is expressed in the thyroid gland. In this study we determine whether these vaccines are able to inhibit autochthonous tumor growth in this animal model. Mice treated with Listeria vaccines expressing E7 had significantly smaller thyroid tumors than did mice treated with controls and possessed higher numbers of antigen-specific CD8(+) T cells within the spleens, tumors, and peripheral blood. This study shows that Listeria-based vaccines are able to slow autochthonous tumor growth and break immunological tolerance. (C) 2008 Elsevier Ltd. All rights reserved.
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