Journal
VACCINE
Volume 26, Issue -, Pages D54-D58Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.07.072
Keywords
Influenza A virus; Pathogenicity; HPAI
Categories
Funding
- EU FP6 program RiviGene [SSPE-CT-2005-022639]
- NIAD-NIH [HHNSN266200700010C]
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In recent years, there has been an increase in outbreaks of highly pathogenic avian influenza (HPAI) in poultry. Occasionally, these outbreaks have resulted in transmission of influenza viruses to humans and other mammals, with symptoms ranging from conjunctivitis to pneumonia and death. Here the current, knowledge of the determinants of pathogenicity of HPAI viruses in mammals is summarized. It is becoming apparent that common mechanisms exist across influenza A virus strains and subtypes, through which influenza viruses adapt to mammals and gain or loose pathogenicity. (c) 2008 Elsevier Ltd. All rights reserved.
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