Journal
VACCINE
Volume 26, Issue 4, Pages 451-459Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.11.049
Keywords
complement; vaccine; polysaccharide
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Funding
- MRC [G0400300] Funding Source: UKRI
- Medical Research Council [G0400300] Funding Source: researchfish
- Medical Research Council [G0400300] Funding Source: Medline
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The complement system, a well-characterised arm of the innate immune system, significantly influences the adaptive immune response via direct cell-cell interaction and maintenance of lymphoid organ architecture. Development of vaccines is a major advance in modern health care. In this review, we highlight the importance of the marginal zone in response to both, polysaccharide and conjugated vaccines, and discuss the relevance of complement herein, based on findings obtained from animal models with specific deletions of certain complement components and from vaccination reports of complement-deficient individuals. We conclude that both, intactness of the complement system and maturity of expression of its components, are relatively more important to aid in the immune response to polysaccharide vaccine than to conjugated vaccines. (C) 2007 Elsevier Ltd. All rights reserved.
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