Journal
VACCINE
Volume 26, Issue 50, Pages 6459-6461Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.06.040
Keywords
Confounding; Vaccination; Influenza vaccine; Randomized controlled trials; Cohort studies
Categories
Funding
- Ministry of Health, Labours and Welfare of Japan
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Confounding is a kind of bias which occurs in a research. Confounding is less frequent in randomized controlled trials (RCT) for evaluation of influenza vaccines. However, there are obstacles or difficulties in conducting RCT for evaluation of influenza vaccines, particularly, in the elderly people. Therefore a retro, spective or prospective cohort study has been primarily performed to evaluate effectiveness of influenza vaccine in elderly people. Confounding by indication or other confounding exist in most observational Studies. Accordingly, at the stage of designing or analyzing a study, confounding should be controlled with a restriction, matching, stratified or multivariate analysis technique. (C) 2008 Elsevier Ltd. All rights reserved.
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