Journal
VACCINE
Volume 26, Issue 48, Pages 6027-6030Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.09.019
Keywords
Cholera toxin B subunit; Oral tolerance; Rice seed
Categories
Funding
- Genomics for Agricultural Innovation [GMC0010]
- Ministry of Agriculture, Forestry and Fisheries of Japan
- Bio-oriented Technology Research Advancement Institution (BRAIN)
- KAKENHI [19780012]
- Grants-in-Aid for Scientific Research [19780012] Funding Source: KAKEN
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Cholera toxin B (C Gamma B) subunit is an efficient mucosal carrier molecule for induction of oral tolerance to antigens and allergens. Here, T-cell epitopes of Cry j 1 and Cry j 2, major allergens in Japanese cedar pollen, were expressed in rice seed as a fusion protein with either CTB or rice glutelin as a control. Feeding mice with rice seed containing CTB-fused T-cell epitopes suppressed allergen-specific IgE responses and pollen-induced clinical symptoms at 50-fold lower doses of T-cell epitopes than required when using control seed. Our findings present a novel potential strategy for immunotherapy of type-I allergy. (C) 2008 Elsevier Ltd. All rights reserved.
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