Journal
VACCINE
Volume 26, Issue 9, Pages 1173-1184Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.12.035
Keywords
17DD vaccine; yellow fever; innate immunity
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Detailed multiparametric phenotypic investigation aiming to characterize the kinetics of the innate immune response in the peripheral blood following 17DD yellow fever (17DD-YF) first-time vaccination was performed. Results showed increased frequency of monocytes and NK cell subpopulations besides unexpected up-regulation of granulocytes activation status (CD28(+)/CD23(+) and CD28(+)/HLA-DR+, respectively). Up-regulation of Fc gamma-R and IL-10-R expression emerge as putative events underlying the mixed pattern of phenotypic features triggered by the 17DD yellow fever (17DD-YF) vaccination. Mixed pattern of chemokine receptors expression further support our hypothesis that a parallel establishment of activation/ modulation microenvironment plays a pivotal role in the protective immunity triggered by the 17DD-YF vaccine. (C) 2008 Elsevier Ltd. All rights reserved.
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