Journal
VACCINE
Volume 26, Issue 24, Pages 3002-3007Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.11.062
Keywords
AIDS; HIV-exposed seronegative individuals; immunology; resistance to infection; immune correlates of protection
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Susceptibility to HIV infection is widely different among individuals, and it is known that individuals can be identified who are repeatedly exposed to HIV but in whom neither infection nor disease are seen. The possibility that sheer Luck is not the only determinant of this phenomenon begun to be considered in 1989 when it was reported that T cell responses to HIV proteins could be detected in antibody-negative sexual partners of known HIV-positive men. In this review we will. summarize the body of knowledge that stemmed from that first observation. (c) 2007 Elsevier Ltd. All rights reserved.
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