Journal
VACCINE
Volume 26, Issue 35, Pages 4594-4601Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.05.089
Keywords
rotavirus; virus-like particles; PCPP; parenteral immunization; single dose
Categories
Funding
- EU [QLK2-CT-2002-01249]
- Fundacao para a Ciencia a Tecnologia [SFRH/BD/9616/2002]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/9616/2002] Funding Source: FCT
Ask authors/readers for more resources
Rotavirus virus-like particles (RV-VLPs) represent a novel strategy for development of a rotavirus subunit vaccine. In this study, RF 8-2/6/7-VLPs with rotavirus VP8 protein (amino acid 1-241 of VP4) fused to the amino terminal end of a truncated VP2, were evaluated for their immunogenic and protective properties. A single intramuscular dose of, either 2 or 20 mu g, RF 8-2/6/7-VLPs alone or combined with a potent adjuvant poly[ di(carboxylatophenoxy)]phosphazene] (PCPP) induced rotavirus-specific serum IgG and IgA, fecal IgG titers that were enhanced 5-90-fold by adjuvant. Passive protective immunity was achieved in offspring to dams vaccinated with 2 and 20 mu g RV-VLPs in presence of adjuvant and 20 mu g RV-VLP without adjuvant. (c) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available