Journal
VACCINE
Volume 26, Issue 34, Pages 4382-4386Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.05.081
Keywords
Japanese encephalitis; virus; vaccine
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Japanese encephalitis (JE) is the most common viral encephalitis in Asia. IC51 is a new Vero cell-derived, inactivated JE virus vaccine with non-inferior immunogenicity (after 2 months) compared to the US-licensed vaccine JE-VAX (R) (mouse brain-derived, inactivated) and with a more convenient (two injections instead of three) intramuscular dose schedule. Adult subjects from two studies were followed-up for comparative immunogenicity (JE-VAX (R)) at 6 months and long-term immunogenicity of IC51 alone at 12 months. At 6 months, immunogenicity was higher with IC51 (seroconversion rate ISCR] 95%; geometric mean titer [GMT] 84) than with JE-VAX (R) (SCR 74%; GMT 34). At 12 months, the SCR was 83% and the GMT (41) remained above the protective titer of 1:10. Most people immunized with IC51 will have protective neutralizing antibody levels for at least a year. (c) 2008 Elsevier Ltd. All rights reserved.
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