Journal
VACCINE
Volume 26, Issue 29-30, Pages 3742-3749Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2008.04.043
Keywords
mathematical modeling; dynamic model; interventions against pandemic
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The limited production capacity for vaccines raises the question what the best strategy is for allocating the vaccine to mitigate an influenza pandemic. We developed an age-structured model for spread of an influenza pandemic and validated it against observations from the Asian flu pandemic. Two strategies were evaluated: vaccination can be implemented at the start of the influenza pandemic, or vaccination will be implemented near the peak of it. Our results suggest prioritizing individuals with a high-risk of complications if a vaccine becomes available during a pandemic. If available at the start, vaccinating school children might be considered since this results in slightly lower expected number of deaths. (C) 2008 Elsevier Ltd. All rights reserved.
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