Seminal Helicobacter pylori Treatment Improves Sperm Motility in Infertile Asthenozoospermic Men

OBJECTIVE To assess the effect of treatment of seminal Helicobacter pylori in infertile asthenozoospermic men. METHODS In all, 223 infertile asthenozoospermic men were consecutively selected. They were subjected to history taking, clinical examination, semen analysis, and estimation of H pylori IgA antibodies in their seminal fluid. Infertile men with high seminal H pylori IgA were subjected to triple drug treatment, omeprazole, 20 mg; tinidazole, 500 mg; and clarithromycin, 250 mg twice a day for 2 weeks. Semen analysis as well as H pylori IgA antibodies was estimated after 3 months. RESULTS In all, 22 of 223 men (9.87%) demonstrated H pylori IgA antibodies in their seminal plasma. After treatment, mean seminal H pylori IgA levels demonstrated significant decrease (1.55 +/- 0.4 vs 0.52 +/- 0.26; 95% confidence interval, 0.83-1.21; P = .001) concomitant with improved progressive as well as nonprogressive sperm motility. H pylori IgA antibodies demonstrated significant negative correlation with progressive sperm motility, nonprogressive sperm motility, normal sperm morphology, and significant positive correlation with immotile sperm motility. CONCLUSION H pylori treatment significantly improves sperm motility in infertile asthenozoospermic men with elevated seminal H pylori IgA. (C) 2014 Elsevier Inc.