Journal
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
Volume 29, Issue 6, Pages 654-663Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.urolonc.2010.01.009
Keywords
Prostate cancer; Genes of biometabolism; Polymorphisms
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Funding
- Fundacao Araucaria
- Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
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Background/objective: Genetic polymorphisms in cytochrome P-450 (CYPs) and glutathione S-transferase (GSTs) genes can influence the appearance of tumors by the formation of new enzymes with altered activities. In the present study, 5 polymorphic variants were examined in 154 patients with prostate carcinoma and in 154 controls. Materials and methods: DNA analysis was carried out through PCR-based methods. The statistical methods used were odds ratio and confidence interval (95% CI), chi(2), Fisher, and Mann-Whitney. Results: The study showed absence of association for CYP1A1*2B, CYP1B1*2, GSTM1*0, and GSTT1*0. The statistical analysis implied a positive association of variant CYP3A4*1B for prostate cancer. The combined analysis of CYP1A1*2B, CYP1B1*2, and CYP3A4*1B genotypes showed positive association. The analysis of histopathologic parameters detected statistically significant differences for Gleason score and biochemistry recurrence risk. The presence of the GSTT1*0 genotype in red meat consumers increased the risk for this disease. Conclusion: Some polymorphic variants analyzed can influence the development and the progression of prostate cancer. (C) 2011 Elsevier Inc. All rights reserved.
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