Journal
UROLOGIC CLINICS OF NORTH AMERICA
Volume 39, Issue 4, Pages 435-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ucl.2012.07.002
Keywords
Prostate cancer; Castration resistant; Castration recurrent; Biology; Mechanism
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Although androgen-deprivation therapy is the standard therapy for advanced and metastatic prostate cancer, this treatment is only palliative. Prostate cancer recurs then grows despite low circulating testicular androgens, using several mechanisms that remain dependent on androgen-receptor signaling in most cases. This article reviews the diversity of mechanisms used for growth by castration-recurrent prostate cancer.
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