Journal
UPSALA JOURNAL OF MEDICAL SCIENCES
Volume 117, Issue 2, Pages 122-131Publisher
UPSALA MED SOC
DOI: 10.3109/03009734.2012.658975
Keywords
Brain tumors; molecular biology; oncogenes; pediatrics; protein phosphorylation; tumor biology
Categories
Funding
- The Swedish Childhood Cancer Foundation
- The Swedish Cancer Society
- The Pediatric Brain Tumor Foundation
- The Swedish Research Council
- Ake Wibergs stiftelse
- Lions Cancerforskningsfond
- Stiftelsen Lars Hiertas Minne
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Myc proteins are often deregulated in human brain tumors, especially in embryonal tumors that affect children. Many observations have shown how alterations of these pleiotropic Myc transcription factors provide initiation, maintenance, or progression of tumors. This review will focus on the role of Myc family members (particularly c-myc and Mycn) in tumors like medulloblastoma and glioma and will further discuss how to target stabilization of these proteins for future brain tumor therapies.
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