Journal
UPSALA JOURNAL OF MEDICAL SCIENCES
Volume 117, Issue 2, Pages 113-121Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/03009734.2012.658976
Keywords
Astrocyte; cell of origin; glioma; glioma-initiating cell; neural stem cell; oligodendrocyte precursor cell
Categories
Funding
- Swedish Cancer Society
- Swedish Research Council
- Association for International Cancer Research
- Swedish Childhood Cancer Foundation
- Swedish Society of Medicine
- Ragnar Soderberg's Foundation
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Glioma is the most frequent primary brain tumor of adults that has a presumably glial origin. Although our knowledge regarding molecular mechanisms and signaling pathways involved in gliomagenesis has increased immensely during the past decade, high-grade glioma remains a lethal disease with dismal prognosis. The failure of current therapies has to a large extent been ascribed the functional heterogeneity of glioma cells. One reason for this heterogeneity is most certainly the large number of variations in genetic alterations that can be found in high-grade gliomas. Another factor that may influence glioma heterogeneity could be the cell type from which the glioma is initiated. The cell of origin for glioma is still undefined, and additional knowledge about this issue may prove critical for a more complete understanding of glioma biology. Based on information from patients, developmental biology, and experimental glioma models, the most putative target cells include astrocytes, neural stem cells, and oligodendrocyte precursor cells, which are all discussed in more detail in this article. Animal modeling of glioma suggests that these three cell types have the capability to be the origin of glioma, and we have reason to believe that, depending on the initiating cell type, prognosis and response to therapy may be significantly different. Thus, it is essential to explore further the role of cellular origin in glioma.
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