Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2015, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2015/247382
Keywords
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Funding
- Foundation for Science and Technology (FCT, Portugal) [SFRH/BD/87658/2012]
- Programa Operacional, Fatores de competitividade-COMPETE
- FCT (Fundacao para a Ciencia e a Tecnologia) [FCT PTDC/SAU-MIC/119069/2010, RECI/EBB-EBI/0179/2012, PEst-OE/EQB/LA0023/2013]
- Programa Operacional Regional do Norte (ON. 2-O Novo Norte)
- QREN
- FEDER
- [PEst-OE/AGR/UI0690/2014]
- Fundação para a Ciência e a Tecnologia [PEst-OE/EQB/LA0023/2013, PEst-OE/AGR/UI0690/2014, PTDC/SAU-MIC/119069/2010, RECI/BBB-EBI/0179/2012, SFRH/BD/87658/2012] Funding Source: FCT
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Candida species have increasingly deserved a special attention among the medical community. In spite of the presence of Candida species as a human commensal, alarming rates of local and systemic infections have been observed, varying from moderate to severe impact. Currently available antifungal drugs have progressively lost their effectiveness, pointing urgently the problem of the microorganisms with acquired-resistance. Natural matrices are secularly used for numerous purposes, being inclusive and highly effective as antimicrobials. Increasing evidence gives a particular emphasis to the contribution of phenolic extracts and related individual compounds. In vitro studies clearly confirm their prominent effects, but the confirmation through in vivo studies, including the involved mechanisms of action, is not so much deepened. Therefore, the present report aims to provide extensive knowledge about all these aspects, highlighting the most efficient phytochemical formulations, including therapeutic doses. Further studies need to be incited to deepen knowledge on this area, namely, focused on clinical trials to provide safer and more effective antimicrobials than the current ones.
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