Reliability of three-dimensional sonographic measurements in early pregnancy using virtual reality

Objective To establish The reliability of three-dimensional (3D) ultrasound measurements in early pregnancy using a virtual reality system (the Barco I-Space). Methods The study included 28 pregnancies with gestational ages ranging from 6 to 14 (median., 10) weeks. 3D volumes were acquired and offline measurements were made, where possible, of the yolk sac diameter, crown-rump length, biparietal diameter, head circumference and abdominal circumference, using specialized 3D imaging software (4DView). The datasets were then transferred to the Barco I-Space, a virtual reality system that allows the observer to perceive depth and interact with volume-rendered (ultrasound) data. The 3D rendered volumes were measured using a virtual pointer, controlled by a wireless joystick. For intraobserver variability, 3D and virtual reality volumes were measured twice by one operator. For interobserver variability, another operator performed the same measurements once. All measurements were repeated three times and their mean values were used for comparisons. Results All intraclass correlation coefficients (ICCs) comparing 4D View measurements with I-Space measurements were > 0.97. Intra- and interobserver ICCs for the 4D View measurements were > 0.96 and for the I-Space ones were > 0.98, representing good agreement. Conclusions The application of virtual reality is a novel method of visualizing 3D ultrasound data and perception of the depth in the I-Space offers possibilities for measuring non-planar structures. We have demonstrated that earl), pregnancy measurements in the I-Space are reliable. New areas of embryonic and fetal biometry can now be explored using ibis technique, which we tentatively name virtual embryoscopy'. Copyright (C) 2008 ISUOG. Published by John Wiley, & Sons, Ltd.