Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 44, Issue 11, Pages 2336-2344Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2018.06.005
Keywords
Acoustic transmission; Insertion loss; Rat skull; Focused ultrasound
Funding
- CEA Technologies for Health transverse program
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In many transcranial ultrasound studies on rats, the transmission factor is assumed to be independent of animal weight and losses resulting from non-normal incidence angles of the beam are not accounted for. In this study, we measured acoustic transmission factors through 13 excised skulls of male Sprague-Dawley rats weighing between 90 and 520 g, at different positions on each skull and at 1, 1.25, 1.5, 1.75 and 2 MHz. Our results revealed that insertion loss through rat skull increases linearly with both body mass and frequency and strongly depends on the position, decreasing from the front to the back and from the midline to the lateral sides. Skull thickness also scales linearly with body mass. Reflection explains the main part of the insertion loss compared with attenuation and aberration. These data are helpful in predicting the acoustic pressure at the focus in the brain. (C) 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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