Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 39, Issue 6, Pages 1120-1127Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2012.12.010
Keywords
Crystalline lens; Young's modulus; Shear viscosity; Laser-induced microbubble; Acoustic radiation force; Ultrasound measurement; Presbyopia
Funding
- National Institutes of Health [EY 018081]
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The mechanical properties of ex vivo animal lenses from three groups were evaluated: old bovine (25-30 mo old, n = 4), young bovine (6 mo old, n = 4) and young porcine (6 mo old, n = 4) eye globes. We measured the dynamics of laser-induced microbubbles created at different locations within the crystalline lenses. An impulsive acoustic radiation force was applied to the microbubble, and the microbubble displacements were measured using a custom-built high pulse repetition frequency ultrasound system. Based on the measured dynamics of the microbubbles, Young's moduli of bovine and porcine lens tissue in the vicinity of the microbubbles were reconstructed. Age-related changes and location-dependent variations in the Young's modulus of the lenses were observed. Near the center, the old bovine lenses had a Young's modulus approximately fivefold higher than that of young bovine and porcine lenses. The gradient of Young's modulus with respect to radial distance was observed in the lenses from three groups. (E-mail: emelian@mail.utexas.edu) (C) 2013 World Federation for Ultrasound in Medicine & Biology.
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