Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 39, Issue 3, Pages 439-448Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2012.10.002
Keywords
Tissue mimicking (TM); Phantom; High intensity focused ultrasound (HIFU); Ultrasound; Polyacrylamide hydrogel (PAG); Bovine serum albumin (BSA); Visualization; Thermal lesion
Funding
- National Research Foundation of Korea
- Ministry of Education, Science and Technology, Republic of Korea [2009-0069017]
- Ministry of Health and Welfare, Republic of Korea [A101727]
- Korea Health Promotion Institute [HI10C1688020013] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2009-0069017] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
An optically transparent tissue-mimicking (TM) phantom whose acoustic properties are close to those of tissue was constructed for visualizing therapeutic effects by high intensity focused ultrasound (HIFU). The TM phantom was designed to improve a widely used standard bovine serum albumin (BSA) polyacrylamide hydrogel (PAG), which attenuated ultrasound far less than tissue and, unlike tissue, did not scatter ultrasound. A modified recipe has been proposed in the study by adding scattering glass beads with diameters of 40-80 mu m (0.002% w/v) and by raising the concentration of acrylamide (30% v/v). The TM BSA-PAG constructed has an acoustic impedance of 1.67 MRayls, a speed of sound of 1576 m/s, an attenuation coefficient of 0.52 dB/cm at 1 MHz, a back-scattering coefficient of 0.242 x 10(-3) 1/sr/cm at 1 MHz and a nonlinear parameter (B/A) of 5.7. These parameters are close to those of liver. The thermal and optical properties are almost the same as the standard BSA-PAG. The characteristic features of the thermal lesions by HIFU were observed to be more accurately visualized in the TM BSA-PAG than in the standard BSA-PAG. In conclusion, the proposed TM BSA-PAG acoustically mimics tissue better than the standard BSA-PAG and is expected to be preferentially used for assuring if a clinical HIFU device produces the thermal lesion as planned. (E-mail: mjchoi@jejunu.ac.kr) (C) 2013 World Federation for Ultrasound in Medicine & Biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available