Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 37, Issue 11, Pages 1952-1957Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2011.08.012
Keywords
Acoustic droplet vaporization; Ultrasound; Monodisperse; Perfluoropentane; Microfluidic
Funding
- [R01EB008733]
- [R21EB011704]
Ask authors/readers for more resources
Liquid perfluorocarbon droplets have been of interest in the medical acoustics community for use as acoustically activated particles for tissue occlusion, imaging and therapeutics. To date, methods to produce liquid perfluorocarbon droplets typically result in a polydisperse size distribution. Because the threshold of acoustic activation is a function of diameter, there would be benefit from a monodisperse population to preserve uniformity in acoustic activation parameters. Through use of a microfluidic device with flow-focusing technology, the production of droplets of perfluoropentane with a uniform size distribution is demonstrated. Stability studies indicate that these droplets are stable in storage for at least two weeks. Acoustic studies illustrate the thresholds of vaporization as a function of droplet diameter, and a logarithmic relationship is observed between acoustic pressure and vaporization threshold within the size ranges studied. Droplets of uniform size have very little variability in acoustic vaporization threshold. Results indicate that microfluidic technology can enable greater manufacturing control of phase-change perfluorocarbons for acoustic droplet vaporization applications. (E-mail: padayton@bme.unc.edu) (C) 2011 World Federation for Ultrasound in Medicine & Biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available