Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 35, Issue 3, Pages 443-446Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2008.09.016
Keywords
Ultrasound; Echo intensity; Neuromuscular disorders; Duchenne muscular dystrophy; Dogs; Muscle
Funding
- Prinses Beatrix Fonds [MAR02-0105]
- Netherlands Organization for Health Research and Development [907 to 00-057]
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In this study, we examined the correlation between muscle ultrasound and muscle structure. Echo intensity (EI) or 14 muscles of two golden retriever muscular dystrophy dogs was correlated to the percentage interstitial fibrous tissue and fat in muscle biopsy. A significant correlation between interstitial fibrous tissue and EI was found (r = 0.87;p < 0.001). The separate influence of interstitial fat on muscle EI could not be established as only little fat was present, We conclude that fibrous tissue causes increased muscle EI. The high correlation between interstitial fibrous tissue and EI makes ultrasound a reliable method to determine severity of structural muscle changes. (E-mail: s.pillen@cukz.umcn.nl) (C) 2009 World Federation for Ultrasound in Medicine & Biology.
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