Journal
ULTRASONICS SONOCHEMISTRY
Volume 21, Issue 1, Pages 310-316Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ultsonch.2013.07.014
Keywords
Drug delivery; Temperature-sensitive liposomes; Thermosensitive polymer; Ultrasound; Cavitation
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [19300182]
- Grants-in-Aid for Scientific Research [19300182, 24650294] Funding Source: KAKEN
Ask authors/readers for more resources
Ultrasound-mediated drug delivery was established using liposomes that were modified with the thermosensitive polymer (TSP) poly(NIPMAM-co-NIPAM), which sensitized the liposomes to high temperatures. TSP-modified liposomes (TSP liposomes) released encapsulated calcein under 1 MHz ultrasound irradiation at 0.5 W/cm(2) for 120 s as well as the case under incubation at 42 degrees C for 15 min. In addition, uptake of the drug released from TSP liposomes by cancer cells was enhanced by ultrasound irradiation. In a cell injury assay using doxorubicin (DOX)-loaded TSP liposomes and ultrasound irradiation, cell viability of HepG2 cells at 6 h after ultrasound irradiation (1 MHz, 0.5 W/cm(2) for 30 s) with DOX-loaded TSP liposomes (TSP/Iipid ratio = 1) was 60%, which was significantly lower than that of the control conditions such as DOX-loaded TSP liposomes alone and DOX-loaded intact liposomes under ultrasound irradiation. (C) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available