Journal
ULTRASONICS SONOCHEMISTRY
Volume 20, Issue 5, Pages 1139-1143Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ultsonch.2013.02.006
Keywords
Ultrasound; Pyrazolol[1,5-a]pyrimidines; Enones; Trifluoromethyl
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Funding
- National Council for Scientific and Technological Development (CNPq/Universal) [578426/2008-0, 471519/2009-0]
- Foundation for Research Support of the State of Rio Grande do Sul (FAPERGS/CNPq-PRONEX) [008/2009, 10/0037-8]
- Coordination for Improvement of Higher Education Personnel (CAPES/PROEX)
- CNPq
- CAPES
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Pyrazolo[1,5-a]pyrimidines were synthesized via the ultrasonic sonochemical method using the cyclo-condensation reaction of 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones [CF3(C)(O)CH = C(R)(OMe) - where R = Me, Bu, i-Bu, Ph, 4-Me-C6H4, 4-F-C6H4, 4-CI-C6H4, 4-Br-C6H4, naphth-2-yl and biphen-4-yl] - with 3-amino-5-methyl-1H-pyrazole in the presence of EtOH for 5 min. This methodology has several advantages, for example, it is a simple procedure, it has an easy work-up, Mild conditions, short reaction times (5 min) and produces satisfactory yields (61-98%). (C) 2013 Elsevier B.V. All rights reserved.
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