Journal
ULTRASONICS SONOCHEMISTRY
Volume 20, Issue 1, Pages 401-407Publisher
ELSEVIER
DOI: 10.1016/j.ultsonch.2012.07.007
Keywords
2-Amino-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile; Multicomponent reactions (MCRs); Ultrasound irradiation; Kojic acid; Green chemistry
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Funding
- research foundation of University of Kashan [159198/I]
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A green and simple approach to assembling of 2-amino-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile scaffolds via three-component reaction of kojic acid, malononitrile, and aromatic aldehydes in aqueous media under ultrasound irradiation is described. The combinatorial synthesis was achieved for this methodology with applying ultrasound irradiation while making use of water as green solvent. In comparison to conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and selectivity without the need for a transition metal or base catalyst are prominent features of this green procedure. (C) 2012 Elsevier B.V. All rights reserved.
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