4.7 Article

A convenient and efficient protocol for the synthesis of 5-aryl-1,3-diphenylpyrazole catalyzed by hydrochloric acid under ultrasound irradiation

Journal

ULTRASONICS SONOCHEMISTRY
Volume 17, Issue 1, Pages 11-13

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.ultsonch.2009.06.015

Keywords

Cyclization; 5-Aryl-1,3-diphenylpyrazole; Synthesis; Heterocycles; Ultrasound

Funding

  1. Natural Science Foundation of Hebei Province, China [B2006000969]

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The synthesis of 5-aryl-1,3-diphenylpyrazole via the reactions of 3-aryl-2,3-epoxy-1-phenyl-1-propanone with phenylhydrazine was carried out in 69-99% yields at room temperature under ultrasound irradiation. This method provides several advantages such as operational simplicity, higher yield and environment friendly. (C) 2009 Elsevier B.V. All rights reserved.

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