Journal
ULTRASONICS
Volume 48, Issue 4, Pages 271-278Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ultras.2008.02.002
Keywords
ultrasound; biological response; wound healing; bone regeneration; cancer therapy; immune response; angiogenesis; hemostasis
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The therapeutic benefits of several existing ultrasound-based therapies such as facilitated drug delivery, tumor ablation and thrombolysis derive largely from physical or mechanical effects. In contrast, ultrasound can also trigger various time-dependent biochemical responses in the exposed biological milieu. Several biological responses to ultrasound exposure have been previously described in the literature but only a handful of these provide therapeutic opportunities. These include the use of ultrasound for healing of soft tissues and bones, the use of ultrasound for inducing non-necrotic tumor atrophy as well as for potentiation of chemotherapeutic drugs, activation of the immune system, angiogenesis and suppression of phagocytosis. A review of these therapeutic opportunities is presented with particular emphasis on their mechanisms. Overall, this review presents the increasing importance of ultrasound's role as a biological sensitizer enabling novel therapeutic strategies. Published by Elsevier B.V.
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