Journal
ULTRAMICROSCOPY
Volume 111, Issue 7, Pages 788-792Publisher
ELSEVIER
DOI: 10.1016/j.ultramic.2010.10.014
Keywords
Diffractive imaging; Single-shot diffraction; Intensity correlations
Categories
Ask authors/readers for more resources
The high intensity of free-electron X-ray light sources may enable structure determinations of viruses or even individual proteins without the encumbrance of first forming crystals. This note compares two schemes of non-crystalline diffraction data collection that have been proposed: serial single-shot data from individual particles, and averaged cross-correlation data from particle ensembles. The information content of these schemes is easily compared and we show that the single-shot approach, although experimentally more challenging, is always superior in this respect. In fact, for 3D structure determination a constraint counting argument shows that the cross-correlation scheme suffers from data deficiency. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available