Journal
TWIN RESEARCH AND HUMAN GENETICS
Volume 16, Issue 1, Pages 271-281Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/thg.2012.140
Keywords
twin family studies; gene finding; longitudinal surveys; biobank; DNA
Categories
Funding
- Netherlands Organisation for Scientific Research, NWO [900-562-137, 904-61-090, 985-10-002, 904-61-193, 56-464-14192, 400-03-330, 480-04-004, 400-07-080, 911-09-032, 451-06-004, 451-08-026, 451-10-005]
- NWO-DFG [DN 58-103]
- Netherlands Organisation for Health Research and Development [ZonMW 3100.0038, 940-37-024, 31160008]
- EMGO+ Institute for Health and Care Research
- Neuroscience Campus Amsterdam
- Center for Medical Systems Biology (CMSB)
- Netherlands Brain Foundation [13F-05(2).47]
- BBMRI - NL [184.021.007]
- GENOMEUTWIN/EU [QLG2-CT-2002-01254]
- National Institutes of Health [NIH 5R37DA018673-03, R01 MH059160, 1RC2 MH089951-01, 4R37DA018673-06, 1R01 MH087646-01A1]
- National Institute of Mental Health [RFA MH08120]
- Brain and Behavior Research Foundation
- FP7 ENGAGE [FP7-HEALTH-F4-2007-201413]
- EU-Marie Curie Research Training Networks [MRTN ct-2006 035987]
- European Research Council [230374-GMI, 284167]
- Rutgers University [3797]
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Over the past 25 years, the Adult Netherlands Twin Register (ANTR) has collected a wealth of information on physical and mental health, lifestyle, and personality in adolescents and adults. This article provides an overview of the sources of information available, the main research findings, and an outlook for the future. Between 1991 and 2012, longitudinal surveys were completed by twins, their parents, siblings, spouses, and offspring. Data are available for 33,957 participants, with most individuals having completed two or more surveys. Smaller projects provided in-depth phenotyping, including measurements of the autonomic nervous system, neurocognitive function, and brain imaging. For 46% of the ANTR participants, DNA samples are available and whole genome scans have been obtained in more than 11,000 individuals. These data have resulted in numerous studies on heritability, gene x environment interactions, and causality, as well as gene finding studies. In the future, these studies will continue with collection of additional phenotypes, such as metabolomic and telomere length data, and detailed genetic information provided by DNA and RNA sequencing. Record linkage to national registers will allow the study of morbidity and mortality, thus providing insight into the development of health, lifestyle, and behavior across the lifespan.
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