Journal
TWIN RESEARCH AND HUMAN GENETICS
Volume 15, Issue 6, Pages 767-774Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/thg.2012.62
Keywords
GWAS; rapid feasible generalized least squares; Minnesota Center for Twin and Family Research
Categories
Funding
- USPHS from the National Institute on Alcohol Abuse and Alcoholism [AA09367, AA11886]
- National Institute on Drug Abuse [DA05147, DA13240, DA024417]
- National Institute on Mental Health [MH066140]
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As part of the Genes, Environment and Development Initiative, the Minnesota Center for Twin and Family Research (MCTFR) undertook a genome-wide association study, which we describe here. A total of 8,405 research participants, clustered in four-member families, have been successfully genotyped on 527,829 single nucleotide polymorphism (SNP) markers using Illumina's Human660W-Quad array. Quality control screening of samples and markers as well as SNP imputation procedures are described. We also describe methods for ancestry control and how the familial clustering of the MCTFR sample can be accounted for in the analysis using a Rapid Feasible Generalized Least Squares algorithm. The rich longitudinal MCTFR assessments provide numerous opportunities for collaboration.
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