Journal
TWIN RESEARCH AND HUMAN GENETICS
Volume 16, Issue 1, Pages 385-390Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/thg.2012.97
Keywords
twins; socioeconomic status; gene-environment interaction; neighborhoods; schools
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Funding
- National Institutes of Health (NIH) center grant [R24-HD042849]
- NIH [R21-AA020588, R21-HD069772]
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Socioeconomic position, racial/ethnic minority status, and other characteristics of the macro-environment may be important moderators of genetic influence on a wide array of psychosocial outcomes. Designed to maximize representation of low socioeconomic status families and racial/ethnic minorities, the Texas Twin Project is an ongoing study of school-age twins (preschool through 12th grade) enrolled in public schools in the Austin, Texas and Houston, Texas metropolitan areas. School rosters are used to identify twin families from a target population with sizable populations of African American (18%), Hispanic/Latino (48%), and non-Hispanic White (27%) children and adolescents, over half of whom meet US guidelines for classification as economically disadvantaged. Initial efforts have focused on a large-scale, family-based survey study involving both parent and child reports of personality, psychopathology, physical health, academic interests, parent-child relationships, and aspects of the home environment. In addition, the Texas Twin Project is the basis for an in-laboratory study of adolescent decision-making, delinquency, and substance use. Future directions include geographic expansion of the sample to the entire state of Texas (with a population of over 25 million) and genotyping of participating twins.
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