Journal
BIOMATERIALS SCIENCE
Volume 3, Issue 4, Pages 564-580Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4bm00441h
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Funding
- NIH Director's Transformative Research Award [1R01HL117326]
- King Abdulaziz City for Science and Technology UC San Diego Joint Center of Excellence in Nanomedicine
- National Science Foundation Graduate Research Fellowship Program
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL117326] Funding Source: NIH RePORTER
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Cardiovascular disease, including myocardial infarction (MI) and peripheral artery disease ( PAD), afflicts millions of people in Unites States. Current therapies are insufficient to restore blood flow and repair the injured heart or skeletal muscle, respectively, which is subjected to ischemic damage following vessel occlusion. Micro- and nano-particles are being designed as delivery vehicles for growth factors, enzymes and/or small molecules to provide a sustained therapeutic stimulus at the injured tissue. Depending on the formulation, the particles can be injected directly into the heart or skeletal muscle, or accumulate at the site of injury following an intravenous injection. In this article we review existing particle based therapies for treating MI and PAD.
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