Journal
TUMOR BIOLOGY
Volume 35, Issue 10, Pages 9993-9997Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-014-2299-9
Keywords
HCC; miR-141; ZEB2; Growth; Motility
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Funding
- State Key Laboratory of Virology of China [2013003]
- Natural Science Foundation of Hubei Province [2010CDB08201]
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Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Increasing evidence suggests that microRNAs (miRNAs) are associated with HCC tumorigenesis. The present study was designed to define the role of miR-141 in HCC. The expression of miR-41 was significantly decreased in four HCC cell lines. Overexpression of miR-141 suppressed both the growth and the motility of HCC cells. Furthermore, we identified zinc finger E-box binding homeobox 2 (ZEB2) as a target of miR-141 and miR-141 functioned as a tumor suppressor via ZEB2 targeting in HCC. These data provide a novel potential therapeutic target for HCC treatment.
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