Journal
TUMOR BIOLOGY
Volume 36, Issue 4, Pages 2277-2285Publisher
SPRINGER
DOI: 10.1007/s13277-014-2835-7
Keywords
Gastric carcinoma; miR-103/107; Multidrug resistance; Caveolin-1
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Funding
- National Science and Technology Major Project [2013ZX09303002]
- Chinese National Foundation of National Sciences [81270036, 81372485, 81372546, 81472193]
- Science and Technology project of Liaoning Province [2013021057]
- Colleges and Universities of Liaoning Province Outstanding Talent Support Plan [LR2014023]
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MicroRNAs (miRNAs) are a class of non-protein-coding small RNAs with the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In the present study, we analyzed miRNA expression levels between multidrug-resistant gastric carcinoma cell line SGC7901/ADR and its parent cell line SGC7901 using a miRNA microarray. MiR-103/107 was downregulated compared with parental SGC7901 cells. Overexpression of miR-103/107 sensitized SGC7901/ADR cells to doxorubicin (DOX), as demonstrated by in vitro and in vivo drug sensitivity assay. We further confirmed that miR-103/107 inhibited P-gp function in gastric cancer SGC7901/ADR cells. Finally, we verified that caveolin-1 (Cav-1), a critical component of lipid rafts, was a target of miR-103/107.
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