Journal
BIOMATERIALS SCIENCE
Volume 3, Issue 5, Pages 753-763Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5bm00046g
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Funding
- National Natural Science Foundation of China [51125014, 51233003]
- Ministry of Science and Technology of China [2011CB606202]
- Natural Science Foundation of Hubei Province of China [2013CFA003]
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In order to produce a more efficient cancer cell death, a dual-functional polypeptide, xPolyR(8)-KLA(TPP), was synthesized by disulfide cross-linking CR8C and C-KLA(TPP). The obtained xPolyR(8)-KLA(TPP) could not only initiate tumor cell apoptosis by C-KLA(TPP) with improved cell penetrating ability, but was also capable of loading and delivering the tumor cell suppressing p53 gene. It was found that, after internalization by cancer cells, the xPolyR(8)-KLA(TPP)/p53 complex released the C-KLA(TPP) moiety and the p53 gene in the cytoplasm due to its reducible disulfide bonds. By regulating both the intrinsic and extrinsic apoptotic pathways, the xPolyR(8)-KLA(TPP)/p53 complex performed as a synergetic system and lead to a more efficient cancer cell death.
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