Journal
TUMOR BIOLOGY
Volume 35, Issue 5, Pages 4757-4764Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-014-1621-x
Keywords
Breast cancer; Gene polymorphism; Haplotype; Iran; Transforming growth factor beta
Categories
Funding
- Shiraz University of Medical Sciences
- Shiraz Institute for Cancer Research
Ask authors/readers for more resources
Transforming growth factor beta 1 (TGF beta 1) is suggested to be involved in the pathogenesis of and in complications with breast cancer (BC). Polymorphisms in TGF beta 1 gene (TGF beta 1) have been suggested by many investigators to have a role in susceptibility to BC; however, many discordant data have been reported. Considering the role of ethnic variations, we performed an association study between TGF beta 1 polymorphisms and BC among Iranian women. We sequenced DNA samples of 110 BC and 110 normal control women for the exons and their adjacent intronic regions of TGF beta 1 using PCR. The allele, genotype, and haplotype frequencies were calculated using PowerMarker V3.25 and R 3.0.2 softwares. Ten single nucleotide polymorphisms (SNPs) were detected. Statistical analysis on the frequency of seven most frequent SNPs, including the three coding SNPs (cSNPs) revealed no significant difference between BC and control women. Moreover, among 11 constructed haplotypes, GTGCCGC was significantly different between two study groups. In conclusion, we found no association between the studied SNPs of TGF beta 1 and BC among Iranian women, but a possible association between GTGCCGC haplotype and BC was seen. However, further studies are suggested to clarify this association.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available