Journal
TUMOR BIOLOGY
Volume 35, Issue 11, Pages 10635-10644Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-014-2627-0
Keywords
Macrophage colony-stimulating factor; Interleukins; Tumor-associated macrophages; Paraptosis; Vascular endothelial growth factor; Angiogenesis; Drug resistance; Cancer stem cells
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Funding
- Department of Biotechnology [BT/01/NE/PS/08]
- Department of Electronics and Information Technology, Government of India [5(9)/2012-n]
- Centre for Nanotechnology, IIT Guwahati
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Tumor growth is influenced by a wide variety of external and internal factors. One of the most important mediators of tumor development is our immune system. The nonstop surveillance of the immune system was originally expected to clear the transformed cells from the body and guard against the development of tumor. But contradictory evidences are reported to show the involvement of immune system in supporting the growth and spread of tumor. Tumor infiltrating immune cells, in addition to harboring immunosuppressive activities, also promote angiogenesis and metastasis of tumor. Many growth factors and cytokines are involved in shaping this complex immune microenvironment of the tumor. Macrophage colony-stimulating factor (MCSF) is one such growth factor which is overexpressed in many tumors. In this review, we summarize the basic biology of MCSF, its role in cancer and discuss the involvement of tumor-associated macrophages (TAMs) in tumor development.
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