Journal
BIOMATERIALS SCIENCE
Volume 3, Issue 7, Pages 1061-1065Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4bm00452c
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Funding
- National Science Foundation [DMR-0748834, DMR-1309525]
- National Institute of Health (NIH Director's New Innovator Award) [1DP2OD007246-01, 1R21CA152627]
- UIUC from NIH National Cancer Institute Alliance for Nanotechnology in Cancer 'Midwest Cancer Nanotechnology Training Center' [R25 CA154015A]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1309525] Funding Source: National Science Foundation
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We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly (ethylene glycol) (PEG) via Click reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.
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