Journal
BIOMATERIALS SCIENCE
Volume 3, Issue 6, Pages 833-841Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5bm00077g
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Funding
- National Natural Science Foundation of China [81071886, 81201804, 81371681]
- Science and Technology Support Program of Jilin province [20090441, 201205006]
- Graduate Innovation Fund of Jilin University [20121118]
- State Key Laboratory of Supramolecular Structure and Materials of Jilin University [SKLSSM 200912, SKLSSM 201317]
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Theranostics is emerging as a popular strategy for cancer therapy; thanks to the development of nano-technology. In this work, we have combined an HSV-TK/GCV suicide gene system and near-infrared quantum dots, as the former is quite effective in liver cancer treatment and the latter facilitates tumor imaging. A folate-modified theranostic liposome (FL/QD-TK) was developed, which is composed of an HSV-TK suicide gene covalently coupling with near-infrared fluorescent CdSeTe/ZnS core/shell quantum dots. The liver cancer-targeting and biosafety of FL/QD-TK were studied in vitro and in vivo. FL/QD-TK exhibited highly specific tumor imaging and strong inhibition of the folate receptor-overexpressed Bel-7402 mouse xenografts without systematic toxicity. This study may shed light on gene delivery and targeted cancer therapy.
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