Journal
TUMOR BIOLOGY
Volume 35, Issue 10, Pages 9469-9477Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-014-2439-2
Keywords
Biomarkers; Quantitative immuno-PCR; Chromatography-mass spectrometry; Nucleic acid aptamer
Categories
Funding
- National Natural Science Foundation of China [81172329, 81372644]
- Chinese National High Tech Program [2012AA02A504, 2012AA02A203, 2011ZX09307-001-05]
- Shanghai Excellent Academic Leader Plan [11XD1403600]
- Cross-Biomedical-Engineering Project of Shanghai Jiao Tong University
- International Cooperative Project from Shanghai Science and Technology Commission [12410706400]
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Enzyme-linked immuno-sorbent assay (ELISA) is widely used for biomarker detection. A good biomarker can distinguish patients from healthy or benign diseases. However, the ELISA method is not suitable for small molecule or trace substance detection. Along with the development of new technologies, an increasing level of biomaterials, especially small molecules, will be identified as novel biomarkers. Quantitative immuno-PCR, chromatography-mass spectrometry, and nucleic acid aptamer are emerging methodologies for detection of small molecule biomarkers, even in living cells. In this review, we focus on these novel technologies and their potential for small molecule biomarkers and living cell analysis.
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