Journal
TUMOR BIOLOGY
Volume 35, Issue 1, Pages 9-20Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-013-1141-0
Keywords
Hepatocellular carcinoma; Specific biomarkers; Diagnosis; Monitoring metastasis; Postoperative recurrence
Categories
Funding
- Projects of Jiangsu Medical Science [HK201102, BL2012053]
- Priority Academic Program Development of Jiangsu Higher Education Institution
- Nantong Society Undertaking and Technological Innovation [HS2012039]
- Post-Doctor Scientific Funds [2012M521108, 2013M53139, JS2012-468]
- International S&T Cooperation Program of China [2013DFA32150]
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Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies worldwide with a multifactorial, multistep, complex process and poor prognosis. Its early diagnosis and metastasis monitoring are of the utmost importance. Hepatoma tissues synthesize various tumor-related proteins, genes, enzymes, microRNA, etc. and then secrete into the blood. Detections of circulating biomarkers are useful to find tumor at an early stage or monitor metastasis after postoperative treatment. This paper summarizes recent studies of specific biomarkers at early diagnosis or in monitoring metastasis or postoperative recurrence of HCC.
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