Journal
TUMOR BIOLOGY
Volume 35, Issue 2, Pages 1351-1356Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-013-1181-5
Keywords
Breast cancer; Tumor invasion; Allele specific; Genotyping; Matrix metalloproteinases; MMP-9 gene
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Funding
- University Grants Commission (UGC)
- Rajeev Gandhi National Fellowship (RGNF), New Delhi, India
- Department of Bio-Technology (DBT), Osmania University-Inter Disciplinary School for Life Science for Advance Research and Education (ISLARE), New Delhi
- UGC Center for Advanced Studies (CAS) II, New Delhi
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Matrix metalloproteinases (MMPs) play an important role in breast cancer tumor invasion and progression. MMP-9 is a member of the MMP family and is also known as Gelatinase B or type IV collagenases (92 kDa) and possesses proteolytic activity against type IV collagen, a major component of the basement membrane. Our study aims to examine the association of Gelatinase B (-1562C > T) promoter polymorphism with breast cancer invasion and progression. The study involves 200 breast cancer patients and age-matched 191 healthy controls. The SNP-1562C > T (rs3918242) in MMP-9 promoter region was examined by allele-specific polymerase chain reaction and gel electrophoresis. The genotypes were determined and compared between patients and controls, and the influence of the polymorphism on clinicopathological data was analyzed. The T allele of the -1562C > T MMP-9 polymorphism was detected more frequently in breast cancer patients than controls (p < 0.001). Our results suggest the clinical importance of MMP-9 gene polymorphism (-1562C > T) in breast cancer patients. The study may also help in identifying individuals at risk of developing breast cancer.
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