Journal
TUMOR BIOLOGY
Volume 31, Issue 3, Pages 217-224Publisher
SPRINGER
DOI: 10.1007/s13277-010-0034-8
Keywords
ADAM9; Adenoid cystic carcinoma; Gene silencing; Metalloproteinase; Metastasis
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Funding
- Chinese National Natural Science Foundation of China [30600715]
- Shanghai Leading Academic Discipline Project [S30206]
- Shanghai Science and Technology Committee [08JC 1404800, 08JC 1414400]
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A disintegrin and metalloproteinase 9 (ADAM9) is a type I transmembrane protein that has been associated with cancer development and metastases. Here, we show that ADAM9 is highly expressed in metastatic cancer tissues and in an adenoid cystic carcinoma cell line with a high metastatic potential. Using RNA interference for gene silencing, we show that ADAM9 is essential for in vitro cancer cell proliferation and invasion as well as in vivo cancer metastasis in an experimental murine model of lung metastases. These data indicate that ADAM9 is potentially an important new therapeutic target for the prevention of tumor metastases in adenoid cystic carcinoma.
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